Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis

Mio Kitano, P. Mark Bloomston

Producción científica: Review articlerevisión exhaustiva

109 Citas (Scopus)

Resumen

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis.

Idioma originalEnglish (US)
Número de artículo38
PublicaciónJournal of Clinical Medicine
Volumen5
N.º3
DOI
EstadoPublished - mar 16 2016
Publicado de forma externa

ASJC Scopus subject areas

  • General Medicine

Huella

Profundice en los temas de investigación de 'Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis'. En conjunto forman una huella única.

Citar esto