Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

R. Hromas; B. Davis; F. J. Rauscher; M. Klemsz; D. Tenen; S. Hoffman; Dawei Xu; J. F. Morris

doi:10.1007/978-3-642-85232-9_16

Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

R. Hromas, B. Davis, F. J. Rauscher, M. Klemsz, D. Tenen, S. Hoffman, Dawei Xu, J. F. Morris

Producción científica: Article › revisión exhaustiva

81 Citas (Scopus)

Resumen

Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

Idioma original	English (US)
Páginas (desde-hasta)	158-164
Número de páginas	7
Publicación	Current topics in microbiology and immunology
Volumen	211
DOI	https://doi.org/10.1007/978-3-642-85232-9_16
Estado	Published - 1996
Publicado de forma externa	Sí

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

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10.1007/978-3-642-85232-9_16

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title = "Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1",

abstract = "Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.",

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T1 - Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

AU - Hromas, R.

AU - Davis, B.

AU - Rauscher, F. J.

AU - Klemsz, M.

AU - Tenen, D.

AU - Hoffman, S.

AU - Xu, Dawei

AU - Morris, J. F.

PY - 1996

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N2 - Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

AB - Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

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Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

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