HBV Therapy Following Unsuccessful Interferon Therapy: How do you see the Role for Oral Therapies?

Grace M. Chee, Fred F. Poordad

Resultado de la investigación: Chapter

Resumen

The original therapy for chronic hepatitis B was conventional interferon, used for up to 24 weeks. This was replaced by peginterferon, which has similar efficacy, but is more convenient, with weekly dosing instead of daily or thrice weekly. Roughly one-third of HBeAg-positive patients respond with seroconversion during the treatment period. Those that respond often have baseline characteristics associated with interferon efficacy. Those that do not respond often require retreatment. This can be done with interferon, an oral antiviral or a combination of both. This chapter discusses the therapeutic options for patients who are non-responders to interferon therapy.

Idioma originalEnglish (US)
Título de la publicación alojadaClinical Dilemmas in Viral Liver Disease
EditorialWiley-Blackwell
Páginas188-191
Número de páginas4
ISBN (versión impresa)9781405179058
DOI
EstadoPublished - mar. 10 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Medicine(all)

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