@article{be75b7c80176492f8a95f7854db2c4d7,
title = "Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration",
abstract = "Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.",
keywords = "Cerebrovascular disease, Dementia, Magnetic resonance imaging, Radiology, Stroke",
author = "Smith, {Eric E.} and Biessels, {Geert Jan} and {De Guio}, Fran{\c c}ois and {de Leeuw}, {Frank Erik} and Simon Duchesne and Marco D{\"u}ring and Richard Frayne and Ikram, {M. Arfan} and Eric Jouvent and MacIntosh, {Bradley J.} and Thrippleton, {Michael J.} and Vernooij, {Meike W.} and Hieab Adams and Backes, {Walter H.} and Lucia Ballerini and Black, {Sandra E.} and Christopher Chen and Rod Corriveau and Charles DeCarli and Greenberg, {Steven M.} and Gurol, {M. Edip} and Michael Ingrisch and Dominic Job and Lam, {Bonnie Y.K.} and Launer, {Lenore J.} and Jennifer Linn and McCreary, {Cheryl R.} and Mok, {Vincent C.T.} and Leonardo Pantoni and Pike, {G. Bruce} and Joel Ramirez and Reijmer, {Yael D.} and Romero, {Jose Rafael} and Stefan Ropele and Rost, {Natalia S.} and Sachdev, {Perminder S.} and Scott, {Christopher J.M.} and Sudha Seshadri and Mukul Sharma and Steven Sourbron and Steketee, {Rebecca M.E.} and Swartz, {Richard H.} and {van Oostenbrugge}, Robert and {van Osch}, Matthias and {van Rooden}, Sanneke and Anand Viswanathan and David Werring and Martin Dichgans and Wardlaw, {Joanna M.}",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = dec,
doi = "10.1016/j.dadm.2019.01.002",
language = "English (US)",
volume = "11",
pages = "191--204",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley and Sons Inc.",
}