Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure

Kristine Y. Deleon-Pennell, Osasere K. Ero, Yonggang Ma, Rugmani Padmanabhan Iyer, Elizabeth R. Flynn, Ingrid Espinoza, Solomon K. Musani, Ramachandran S. Vasan, Michael E. Hall, Ervin R. Fox, Merry L. Lindsey

Producción científica: Articlerevisión exhaustiva

11 Citas (Scopus)

Resumen

We hypothesized that identifying plasma glycoproteins that predict the development of heart failure following myocardial infarction (MI) could help to stratify subjects at risk. Plasma collected at visit 2 (2005-2008) from an MI subset of Jackson Heart Study participants underwent glycoproteomics and was grouped by the outcome: (1) heart failure hospitalization after visit 2 (n = 15) and (2) without hospitalization by 2012 (n = 45). Proteins were mapped for biological processes and functional pathways using Ingenuity Pathway Analysis and linked to clinical characteristics. A total of 198 glycopeptides corresponding to 88 proteins were identified (data available via ProteomeXchange with identifier PXD009870). Of these, 14 glycopeptides were significantly different between MI and MI + HF groups and corresponded to apolipoprotein (Apo) F, transthyretin, Apo C-IV, prostaglandin-D2 synthase, complement C9, and CD59 (p < 0.05 for all). All proteins were elevated in the MI + HF group, except CD59, which was lower. Four canonical pathways were upregulated in the MI + HF group (p < 0.05 for all): acute phase response, liver X receptor/retinoid X receptor, and macrophage reactive oxygen species generation. The coagulation pathway was significantly downregulated in the MI + HF group (p < 0.05). Even after adjustment for age and sex, Apo F was associated with the increased risk for heart failure (OR = 21.84; 95% CI 3.20-149.14). In conclusion, glycoproteomic profiling provided candidate early MI predictors of later progression to heart failure.

Idioma originalEnglish (US)
Páginas (desde-hasta)1272-1280
Número de páginas9
PublicaciónACS Omega
Volumen4
N.º1
DOI
EstadoPublished - ene 15 2019
Publicado de forma externa

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

Huella

Profundice en los temas de investigación de 'Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure'. En conjunto forman una huella única.

Citar esto