Glucose metabolism in obesity and type 2 diabetes

R. C. Bonadonna, R. A. De Fronzo

Resultado de la investigación: Articlerevisión exhaustiva

40 Citas (Scopus)


The aim of this review is to provide a comprehensive summary of the subject of glucose metabolism in normal and obese subjects, and in those with type 2 diabetes. The following topics are discussed: - Glucose and insulin metabolism, including characterization of the role of various organs in maintaining glucose homeostasis in the basal state and after food. - The action of insulin and the concept of insulin resistance, its main characteristics as revealed by studies of glucose metabolism in liver and skeletal muscle, the two organs primarily involved. Changes in insulin secretion in obese subjects and in diabetics are reviewed. - Finally, the development of diabetes as a consequence of increasing insulin resistance in the obese diabetic subject is discussed. The principal features - insulin resistance, elevated free fatty acid levels and glucotoxicity - are emphasized. A possible explanation of how obesity leads to diabetes, emphasizing the role played by upper body fat distribution, is provided.

Idioma originalEnglish (US)
Páginas (desde-hasta)112-135
Número de páginas24
PublicaciónDiabete et Metabolisme
N.º1 BIS
EstadoPublished - 1991
Publicado de forma externa

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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