The relative contributions of impaired insulin secretion and of tissue insensitivity to insulin to the carbohydrate intolerance of uremia were investigated in 10 chronically uremic subjects. Two types of glucose-clamp experiments were performed in each patient before and after 10 wk of thrice weekly hemodialysis. In both types the blood glucose concentration was maintained at a constant level by the periodic adjustment of a variable glucose infusion with a negative feedback formula. The hyperglycemic and euglycemic clamp techniques demonstrated tissue insensitivity to insulin to be the dominant carbohydrate defect in uremia.
|Idioma original||English (US)|
|Número de páginas||11|
|Publicación||Journal of Clinical Investigation|
|Estado||Published - 1978|
|Publicado de forma externa||Sí|
ASJC Scopus subject areas