Genomic organization and localization of mouse NMA/BAMBI: Possible implications related to ameloblastoma formation

C. Knight, P. Papagerakis, D. Simmons, A. Berdal, M. MacDougall

Producción científica: Articlerevisión exhaustiva

4 Citas (Scopus)

Resumen

Our laboratory has determined the DNA sequence and transcriptional expression pattern of a mouse cDNA clone termed Nma/BAMBI. This clone encodes a highly conserved protein with 89% identity to the human homologue (termed Nma) and 78% similarity to the Xenopus homologue (termed BAMBI) at the predicted amino acid level. Nma/BAMBI encodes a 260-amino-acid transmembrane protein that has homology to the transforming growth factor (TGF) β type I receptor family. This protein contains an extracellular ligand binding domain, a 24-amino-acid transmembrane domain, and a short intracellular domain that lacks a functional serine/threonine kinase domain. It is believed that Nma/BAMBI is important in the negative regulation of TGFβ signal transduction pathways during development and has implications in tumor progression. We have determined the genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2. Furthermore, we report the production and utilization of an anti-peptide antibody in preliminary immunohistochemical analysis of an ameloblastoma.

Idioma originalEnglish (US)
Páginas (desde-hasta)359-364
Número de páginas6
PublicaciónConnective Tissue Research
Volumen43
N.º2-3
DOI
EstadoPublished - 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Rheumatology
  • Cell Biology
  • Orthopedics and Sports Medicine

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