Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Yi Zhou Jiang; Ding Ma; Chen Suo; Jinxiu Shi; Mengzhu Xue; Xin Hu; Yi Xiao; Ke Da Yu; Yi Rong Liu; Ying Yu; Yuanting Zheng; Xiangnan Li; Chenhui Zhang; Pengchen Hu; Jing Zhang; Qi Hua; Jiyang Zhang; Wanwan Hou; Luyao Ren; Ding Bao; Bingying Li; Jingcheng Yang; Ling Yao; Wen Jia Zuo; Shen Zhao; Yue Gong; Yi Xing Ren; Ya Xin Zhao; Yun Song Yang; Zhenmin Niu; Zhi Gang Cao; Daniel G. Stover; Claire Verschraegen; Virginia Kaklamani; Anneleen Daemen; John R. Benson; Kazuaki Takabe; Fan Bai; Da Qiang Li; Peng Wang; Leming Shi; Wei Huang; Zhi Ming Shao

doi:10.1016/j.ccell.2019.02.001

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Yi Zhou Jiang, Ding Ma, Chen Suo, Jinxiu Shi, Mengzhu Xue, Xin Hu, Yi Xiao, Ke Da Yu, Yi Rong Liu, Ying Yu, Yuanting Zheng, Xiangnan Li, Chenhui Zhang, Pengchen Hu, Jing Zhang, Qi Hua, Jiyang Zhang, Wanwan Hou, Luyao Ren, Ding BaoBingying Li, Jingcheng Yang, Ling Yao, Wen Jia Zuo, Shen Zhao, Yue Gong, Yi Xing Ren, Ya Xin Zhao, Yun Song Yang, Zhenmin Niu, Zhi Gang Cao, Daniel G. Stover, Claire Verschraegen, Virginia Kaklamani, Anneleen Daemen, John R. Benson, Kazuaki Takabe, Fan Bai, Da Qiang Li, Peng Wang, Leming Shi, Wei Huang, Zhi Ming Shao

Producción científica: Article › revisión exhaustiva

637 Citas (Scopus)

Resumen

Jiang et al. characterize primary Chinese triple-negative breast cancer (TNBC) and classify it into four subtypes. They find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss.

Idioma original	English (US)
Páginas (desde-hasta)	428-440.e5
Publicación	Cancer Cell
Volumen	35
N.º	3
DOI	https://doi.org/10.1016/j.ccell.2019.02.001
Estado	Published - mar 18 2019

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2019.02.001

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Jiang, Y. Z., Ma, D., Suo, C., Shi, J., Xue, M., Hu, X., Xiao, Y., Yu, K. D., Liu, Y. R., Yu, Y., Zheng, Y., Li, X., Zhang, C., Hu, P., Zhang, J., Hua, Q., Zhang, J., Hou, W., Ren, L., ... Shao, Z. M. (2019). Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies. Cancer Cell, 35(3), 428-440.e5. https://doi.org/10.1016/j.ccell.2019.02.001

Jiang, YZ, Ma, D, Suo, C, Shi, J, Xue, M, Hu, X, Xiao, Y, Yu, KD, Liu, YR, Yu, Y, Zheng, Y, Li, X, Zhang, C, Hu, P, Zhang, J, Hua, Q, Zhang, J, Hou, W, Ren, L, Bao, D, Li, B, Yang, J, Yao, L, Zuo, WJ, Zhao, S, Gong, Y, Ren, YX, Zhao, YX, Yang, YS, Niu, Z, Cao, ZG, Stover, DG, Verschraegen, C, Kaklamani, V, Daemen, A, Benson, JR, Takabe, K, Bai, F, Li, DQ, Wang, P, Shi, L, Huang, W & Shao, ZM 2019, 'Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies', Cancer Cell, vol. 35, n.º 3, pp. 428-440.e5. https://doi.org/10.1016/j.ccell.2019.02.001

@article{466c13da4ef3468995dd2fbb40163047,

title = "Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies",

abstract = "Jiang et al. characterize primary Chinese triple-negative breast cancer (TNBC) and classify it into four subtypes. They find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss.",

keywords = "genomic, molecular subtype, precision therapies, target, transcriptomic, triple-negative breast cancer",

author = "Jiang, {Yi Zhou} and Ding Ma and Chen Suo and Jinxiu Shi and Mengzhu Xue and Xin Hu and Yi Xiao and Yu, {Ke Da} and Liu, {Yi Rong} and Ying Yu and Yuanting Zheng and Xiangnan Li and Chenhui Zhang and Pengchen Hu and Jing Zhang and Qi Hua and Jiyang Zhang and Wanwan Hou and Luyao Ren and Ding Bao and Bingying Li and Jingcheng Yang and Ling Yao and Zuo, {Wen Jia} and Shen Zhao and Yue Gong and Ren, {Yi Xing} and Zhao, {Ya Xin} and Yang, {Yun Song} and Zhenmin Niu and Cao, {Zhi Gang} and Stover, {Daniel G.} and Claire Verschraegen and Virginia Kaklamani and Anneleen Daemen and Benson, {John R.} and Kazuaki Takabe and Fan Bai and Li, {Da Qiang} and Peng Wang and Leming Shi and Wei Huang and Shao, {Zhi Ming}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = mar,

day = "18",

doi = "10.1016/j.ccell.2019.02.001",

language = "English (US)",

volume = "35",

pages = "428--440.e5",

journal = "Cancer Cell",

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T1 - Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers

T2 - Subtypes and Treatment Strategies

AU - Jiang, Yi Zhou

AU - Ma, Ding

AU - Suo, Chen

AU - Shi, Jinxiu

AU - Xue, Mengzhu

AU - Hu, Xin

AU - Xiao, Yi

AU - Yu, Ke Da

AU - Liu, Yi Rong

AU - Yu, Ying

AU - Zheng, Yuanting

AU - Li, Xiangnan

AU - Zhang, Chenhui

AU - Hu, Pengchen

AU - Zhang, Jing

AU - Hua, Qi

AU - Zhang, Jiyang

AU - Hou, Wanwan

AU - Ren, Luyao

AU - Bao, Ding

AU - Li, Bingying

AU - Yang, Jingcheng

AU - Yao, Ling

AU - Zuo, Wen Jia

AU - Zhao, Shen

AU - Gong, Yue

AU - Ren, Yi Xing

AU - Zhao, Ya Xin

AU - Yang, Yun Song

AU - Niu, Zhenmin

AU - Cao, Zhi Gang

AU - Stover, Daniel G.

AU - Verschraegen, Claire

AU - Kaklamani, Virginia

AU - Daemen, Anneleen

AU - Benson, John R.

AU - Takabe, Kazuaki

AU - Bai, Fan

AU - Li, Da Qiang

AU - Wang, Peng

AU - Shi, Leming

AU - Huang, Wei

AU - Shao, Zhi Ming

PY - 2019/3/18

Y1 - 2019/3/18

N2 - Jiang et al. characterize primary Chinese triple-negative breast cancer (TNBC) and classify it into four subtypes. They find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss.

AB - Jiang et al. characterize primary Chinese triple-negative breast cancer (TNBC) and classify it into four subtypes. They find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss.

KW - genomic

KW - molecular subtype

KW - precision therapies

KW - target

KW - transcriptomic

KW - triple-negative breast cancer

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ER -

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

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