@article{466c13da4ef3468995dd2fbb40163047,
title = "Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies",
abstract = "Jiang et al. characterize primary Chinese triple-negative breast cancer (TNBC) and classify it into four subtypes. They find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss.",
keywords = "genomic, molecular subtype, precision therapies, target, transcriptomic, triple-negative breast cancer",
author = "Jiang, {Yi Zhou} and Ding Ma and Chen Suo and Jinxiu Shi and Mengzhu Xue and Xin Hu and Yi Xiao and Yu, {Ke Da} and Liu, {Yi Rong} and Ying Yu and Yuanting Zheng and Xiangnan Li and Chenhui Zhang and Pengchen Hu and Jing Zhang and Qi Hua and Jiyang Zhang and Wanwan Hou and Luyao Ren and Ding Bao and Bingying Li and Jingcheng Yang and Ling Yao and Zuo, {Wen Jia} and Shen Zhao and Yue Gong and Ren, {Yi Xing} and Zhao, {Ya Xin} and Yang, {Yun Song} and Zhenmin Niu and Cao, {Zhi Gang} and Stover, {Daniel G.} and Claire Verschraegen and Virginia Kaklamani and Anneleen Daemen and Benson, {John R.} and Kazuaki Takabe and Fan Bai and Li, {Da Qiang} and Peng Wang and Leming Shi and Wei Huang and Shao, {Zhi Ming}",
note = "Funding Information: This manuscript was written on behalf of AME Breast Cancer Collaborative Group. We are grateful to the patients and their families who contributed to this study. This study was funded by grants from the National Natural Science Foundation of China ( 81874112 , 81572583 , 81372848 , 81370075 , 31720103909 , 31671368 , and 31671380 ), the Training Plan of Excellent Talents in Shanghai Municipality Health System ( 2017YQ038 ), the “Chen Guang” project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation ( 17CG01 ), Shanghai Pujiang Program ( 18PJD007 ), Shanghai Leading Talent Training Program , the Training Plan of Excellent Talents of FUSCC ( YJYQ201602 ), the Municipal Project for Developing Emerging and Frontier Technology in Shanghai Hospitals ( SHDC12010116 ), the Cooperation Project of Conquering Major Diseases in Shanghai Municipality Health System ( 2013ZYJB0302 ), the Innovation Team of Ministry of Education ( IRT1223 ), the Shanghai Key Laboratory of Breast Cancer ( 12DZ2260100 ), the National Key R&D Project of China ( 2016YFC0901704 , 2017YFC0907502 , 2017YFC0907503 , 2017YFC0907000 , and 2017YFF0204600 ), Shandong Province Key R&D Project ( 2017CXGC1209 ), and the Shanghai Municipal Science and Technology Major Project ( 2017SHZDZX01 , 18JC1420100 , and 15411953300 ). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We also thank Dr. Stephanie Fortier, Dr. Charles Perou, and Dr. Mien-Chie Hung for editing the manuscript. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = mar,
day = "18",
doi = "10.1016/j.ccell.2019.02.001",
language = "English (US)",
volume = "35",
pages = "428--440.e5",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}