Genome-wide meta-analysis identifies 3 novel loci associated with stroke

for the MEGASTROKE consortium and the International Stroke Genetics Consortium

Producción científica: Articlerevisión exhaustiva

68 Citas (Scopus)

Resumen

We conducted a European-only and transancestral genome-wide association meta-analysis in 72,147 stroke patients and 823,869 controls using data from UK Biobank (UKB) and the MEGASTROKE consortium. We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E-8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04–1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E-8, OR = 1.04, 95% CI = 1.03–1.06) and near DYRK1A (rs720470; p = 6.1E-9, OR = 1.05, 95% CI = 1.03–1.07) at genome-wide significance for stroke. Effect sizes of known stroke loci were highly correlated between UKB and MEGASTROKE. Using Mendelian randomization, we further show that genetic variation in the nitric oxide synthase–nitric oxide pathway in part affects stroke risk via variation in blood pressure. Ann Neurol 2018;84:934–939.

Idioma originalEnglish (US)
Páginas (desde-hasta)934-939
Número de páginas6
PublicaciónAnnals of neurology
Volumen84
N.º6
DOI
EstadoPublished - dic 2018

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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