Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept

Psychosis Endophenotypes International Consortium

Resultado de la investigación: Articlerevisión exhaustiva

155 Citas (Scopus)

Resumen

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Idioma originalEnglish (US)
Páginas (desde-hasta)420-431
Número de páginas12
PublicaciónNature Neuroscience
Volumen19
N.º3
DOI
EstadoPublished - feb 23 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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