Genetic basis of diabetic nephropathy

Hernan Rincon-Choles, Farook Thameem, Donna M. Lehman, Rector Arya, Nedal Arar, Ravindranath Duggirala, Michael P. Stern, Hanna E. Abboud

Resultado de la investigación: Articlerevisión exhaustiva

10 Citas (Scopus)

Resumen

Diabetes mellitus is the leading cause of end-stage renal disease. Development and progression of diabetic nephropathy result from a combination of genetic susceptibility and metabolic and hemodynamic abnormalities. In America, some racial and ethnic minorities have a significant burden of diabetic nephropathy, and, although genetic studies suggest that inherited factors play a major role in the pathogenesis of diabetic nephropathy, little information has been gained on the genes and molecular mechanisms involved. The genetic background of diabetic nephropathy is believed to be polygenic, and the genes predisposing to the development and progression of diabetic nephropathy are actively being investigated. New knowledge in identifying and understanding the role of susceptibility gene(s) will provide valuable information that could help develop new preventive and therapeutic strategies.

Idioma originalEnglish (US)
Páginas (desde-hasta)555-561
Número de páginas7
PublicaciónAmerican Journal of Therapeutics
Volumen12
N.º6
DOI
EstadoPublished - nov. 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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