@article{4a08a940387f454ea9ed2bbca8355060,
title = "Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis",
abstract = "Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis.",
author = "Philip Washbourne and Thompson, {Peter M.} and Mario Carta and Costa, {Edmar T.} and Mathews, {James R.} and Guillermina Lopez-Bendit{\'o} and Zolt{\'a}n Moln{\'a}r and Becher, {Mark W.} and Valenzuela, {C. Fernando} and Partridge, {L. Donald} and Wilson, {Michael C.}",
note = "Funding Information: We thank J. Plomp for advice and help in embryonic neuromuscular electrophysiology, S. Nixon for technical assistance, E. Padilla at the UNM-HSC Animal Resource Facility for maintaining the mouse colony and G. Adamson at the UC Davis EM Pathology lab for help with electron microscopy. We also thank P. De Camilli and A. Klip for antisera, and B. Shuttleworth and L. Anna Cunningham for discussions and for reading the manuscript. The work was supported by NIH MH 4-8989 (M.C.W.).",
year = "2002",
month = jan,
doi = "10.1038/nn783",
language = "English (US)",
volume = "5",
pages = "19--26",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "1",
}