Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Philip Washbourne, Peter M. Thompson, Mario Carta, Edmar T. Costa, James R. Mathews, Guillermina Lopez-Benditó, Zoltán Molnár, Mark W. Becher, C. Fernando Valenzuela, L. Donald Partridge, Michael C. Wilson

Resultado de la investigación: Articlerevisión exhaustiva

406 Citas (Scopus)

Resumen

Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis.

Idioma originalEnglish (US)
Páginas (desde-hasta)19-26
Número de páginas8
PublicaciónNature Neuroscience
Volumen5
N.º1
DOI
EstadoPublished - ene. 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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