Generation of allospecffic natural killer cells by stimulation across a polymorphism of HLA-C

Marco Colonna, Edward G. Brooks, Michela Falco, Giovan Battista Ferrara, Jack L. Strominger

Producción científica: Articlerevisión exhaustiva

232 Citas (Scopus)

Resumen

The cytotoxicity of human natural killer (NK) cells is modulated by the major histocom-patibility complex human leukocyte antigen (HLA)-C molecules on the surface of the target cell. Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-CfAsn77, Lys80)] by stimulation with target cells that were homozygous for HLA-C(Ser77, Asn80); the reciprocal stimulation yielded NK cells specific for the NK-2 alloantigen. However, neither homozygous target cell stimulated the generation of alloreactive NK cells from heterozygous individuals. Thus, these data reveal an unanticipated difference between human NK alloreactivity defined by this system and murine "hybrid resistance.".

Idioma originalEnglish (US)
Páginas (desde-hasta)1121-1124
Número de páginas4
PublicaciónScience
Volumen260
N.º5111
EstadoPublished - 1993
Publicado de forma externa

ASJC Scopus subject areas

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