Gender dimorphisms in progenitor and stem cell function in cardiovascular disease

Jeremy L. Herrmann, Aaron M. Abarbanell, Brent R. Weil, Mariuxi C. Manukyan, Jeffrey A. Poynter, Yue Wang, Arthur C. Coffey, Daniel R. Meldrum

Producción científica: Review articlerevisión exhaustiva

32 Citas (Scopus)

Resumen

Differences in cardiovascular disease outcomes between men and women have long been recognized and attributed, in part, to gender and sex steroids. Gender dimorphisms also exist with respect to the roles of progenitor and stem cells in post-ischemic myocardial and endothelial repair and regeneration. Understanding how these cells are influenced by donor gender and the recipient hormonal milieu may enable researchers to further account for the gender-related disparities in clinical outcomes as well as utilize the beneficial effects of these hormones to optimize transplanted cell function and survival. This review discusses (1) the cardiovascular effects of sex steroids (specifically estradiol and testosterone); (2) the therapeutic potentials of endothelial progenitor cells, mesenchymal stem cells, and embryonic stem cells; and (3) the direct effect of sex steroids on these cell types.

Idioma originalEnglish (US)
Páginas (desde-hasta)103-113
Número de páginas11
PublicaciónJournal of Cardiovascular Translational Research
Volumen3
N.º2
DOI
EstadoPublished - abr 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)
  • Genetics
  • Molecular Medicine
  • Pharmaceutical Science

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