GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland

R. Strong; C. Hale; M. A. Moore; M. Wessels-Reiker; H. J. Armbrecht; Arlan G Richardson

doi:10.1016/0304-3940(90)90140-5

GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland

R. Strong
, C. Hale
, M. A. Moore
, M. Wessels-Reiker
, H. J. Armbrecht
, Arlan G Richardson

Barshop Institute

Producción científica: Article › revisión exhaustiva

3 Citas (Scopus)

Resumen

Chromaffin cell γ-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.

Idioma original	English (US)
Páginas (desde-hasta)	175-180
Número de páginas	6
Publicación	Neuroscience Letters
Volumen	117
N.º	1-2
DOI	https://doi.org/10.1016/0304-3940(90)90140-5
Estado	Published - sept 4 1990

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(90)90140-5

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@article{d2622ac3caab480eaee4312c75aab5be,

title = "GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland",

abstract = "Chromaffin cell γ-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.",

keywords = "Adrenal gland, Bicuculline, GABA, Reserpine, Tyrosine hydroxylase, Tyrosine hydroxylase mRNA",

author = "R. Strong and C. Hale and Moore, \{M. A.\} and M. Wessels-Reiker and Armbrecht, \{H. J.\} and Richardson, \{Arlan G\}",

note = "Funding Information: This work was supported by the Geriatric Research, Education and Clinical Center of the St. Louis VA Medical Center, by a grant from the Merit Review Research Program of the Medical Research Service and by NIH Grant AG01548. We thank Dr. Karen O'Malley for her kind donation of the TH.36 cDNA probe.",

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doi = "10.1016/0304-3940(90)90140-5",

language = "English (US)",

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pages = "175--180",

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TY - JOUR

T1 - GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland

AU - Strong, R.

AU - Hale, C.

AU - Moore, M. A.

AU - Wessels-Reiker, M.

AU - Armbrecht, H. J.

AU - Richardson, Arlan G

N1 - Funding Information: This work was supported by the Geriatric Research, Education and Clinical Center of the St. Louis VA Medical Center, by a grant from the Merit Review Research Program of the Medical Research Service and by NIH Grant AG01548. We thank Dr. Karen O'Malley for her kind donation of the TH.36 cDNA probe.

PY - 1990/9/4

Y1 - 1990/9/4

N2 - Chromaffin cell γ-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.

AB - Chromaffin cell γ-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.

KW - Adrenal gland

KW - Bicuculline

KW - GABA

KW - Reserpine

KW - Tyrosine hydroxylase

KW - Tyrosine hydroxylase mRNA

UR - https://www.scopus.com/pages/publications/0024990287

UR - https://www.scopus.com/pages/publications/0024990287#tab=citedBy

U2 - 10.1016/0304-3940(90)90140-5

DO - 10.1016/0304-3940(90)90140-5

M3 - Article

C2 - 1981253

AN - SCOPUS:0024990287

SN - 0304-3940

VL - 117

SP - 175

EP - 180

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland

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