Further studies of salivary inhibition of hiv-1 infectivity

Chih Ko Yeh, Beverly Handelman, Philip C. Fox, Bruce J. Baum

Producción científica: Articlerevisión exhaustiva

39 Citas (Scopus)

Resumen

An HIV-l/ATH8-cell cytopathic system was used to characterize the previously reported anti-HIV-1 activity of human saliva. Inhibitory activity was demonstrated by monitoring viable cell counts, HIV-1 p24 core antigen, and reverse transcriptase levels. Nonfiltered whole saliva, sterilized by irradiation, protected the ATH8 cells from HIV-1 infection. When HIV-1/saliva mixtures were filtered following incubation, the quantity of virus was significantly less (˜50%) than in HIV-1/media-filtered controls, suggesting that salivary aggregation and/or agglutination may be involved in the inhibitory activity. However, a sufficient number of apparently morphologically intact viral particles were still present in the HIV-1/saliva filtrates to lead to infection. When saliva was filtered prior to incubation with HIV-1, these filtrates showed substantial inhibitory activity, although reduced compared with that of non-prefiltered saliva. We conclude that saliva likely has several means by which to inhibit HIV-1 infectivity.

Idioma originalEnglish (US)
Páginas (desde-hasta)898-903
Número de páginas6
PublicaciónJournal of Acquired Immune Deficiency Syndromes
Volumen5
N.º9
EstadoPublished - sept 1992
Publicado de forma externa

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Huella

Profundice en los temas de investigación de 'Further studies of salivary inhibition of hiv-1 infectivity'. En conjunto forman una huella única.

Citar esto