Resumen
An HIV-l/ATH8-cell cytopathic system was used to characterize the previously reported anti-HIV-1 activity of human saliva. Inhibitory activity was demonstrated by monitoring viable cell counts, HIV-1 p24 core antigen, and reverse transcriptase levels. Nonfiltered whole saliva, sterilized by irradiation, protected the ATH8 cells from HIV-1 infection. When HIV-1/saliva mixtures were filtered following incubation, the quantity of virus was significantly less (˜50%) than in HIV-1/media-filtered controls, suggesting that salivary aggregation and/or agglutination may be involved in the inhibitory activity. However, a sufficient number of apparently morphologically intact viral particles were still present in the HIV-1/saliva filtrates to lead to infection. When saliva was filtered prior to incubation with HIV-1, these filtrates showed substantial inhibitory activity, although reduced compared with that of non-prefiltered saliva. We conclude that saliva likely has several means by which to inhibit HIV-1 infectivity.
Idioma original | English (US) |
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Páginas (desde-hasta) | 898-903 |
Número de páginas | 6 |
Publicación | Journal of Acquired Immune Deficiency Syndromes |
Volumen | 5 |
N.º | 9 |
Estado | Published - sept 1992 |
Publicado de forma externa | Sí |
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)