Fungemia caused by an amphotericin B-resistant isolate of Sporothrix schenckii. Successful treatment with itraconazole

J. H. Baker, H. C. Goodpasture, H. R. Kuhns, M. G. Rinaldi

Resultado de la investigación: Articlerevisión exhaustiva

32 Citas (Scopus)

Resumen

A 58-year-old, alcoholic, diabetic man presented with multiple, ulcerated skin lesions and polymicrobial septicemia. Sporothrix schenckii was recovered from blood cultures and was resistant to amphotericin B by in vitro testing. Amphotericin B therapy failed, but the patient responded dramatically to itraxonazole therapy, only to relapse 3 months after therapy was stopped. Reinstitution of itraconazole therapy has produced another dramatic response. This report is noteworthy for three reasons. First, to our knowledge, it represents only the second reported instance of fungemia with S schenckii that responded to medical therapy. Second, it illustrates that in vitro antifungal susceptibility tests may predict clinical infection response to drug therapy. Third, it suggests that itraconazole has significant promise in treating systemic sporotrichosis.

Idioma originalEnglish (US)
Páginas (desde-hasta)1279-1281
Número de páginas3
PublicaciónArchives of Pathology and Laboratory Medicine
Volumen113
N.º11
EstadoPublished - 1989
Publicado de forma externa

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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