Functional independency between catalytic activity and subcellular targeting of polo-like kinase-1. Phenotypes of ectopic overexpression of various mutants

Biochemistry, Genetics and Molecular Biology

• Polo-Like Kinase 100%
• Cell Cycle M Phase 45%
• Phosphorylation 27%
• Enzymatic Activity 18%
• N-Terminus 9%
• Mutation 9%
• Phenotype 9%
• Ectopic Expression 9%
• C-Terminus 9%
• Conformational Change 9%
• Kinase 9%
• Point Mutation 9%
• Subcellular Localization 9%
• Mutant 9%
• Independence 9%

Chemistry

• Chemical Activation 36%
• Phosphorylation 27%
• Mutation 18%
• Subcellular Localization 9%
• Procedure 9%