Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

W. Gibson Wood; Christine Gorka; H. James Armbrecht; Lisa S. Williamson; Randy Strong

doi:10.1016/0024-3205(86)90360-7

Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

W. Gibson Wood, Christine Gorka, H. James Armbrecht, Lisa S. Williamson, Randy Strong

Producción científica: Article › revisión exhaustiva

15 Citas (Scopus)

Resumen

This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.

Idioma original	English (US)
Páginas (desde-hasta)	2089-2095
Número de páginas	7
Publicación	Life Sciences
Volumen	39
N.º	22
DOI	https://doi.org/10.1016/0024-3205(86)90360-7
Estado	Published - dic 1 1986
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(86)90360-7

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title = "Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice",

abstract = "This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.",

author = "{Gibson Wood}, W. and Christine Gorka and {James Armbrecht}, H. and Williamson, {Lisa S.} and Randy Strong",

note = "Funding Information: This work was supported by the Medical Research Service of the Veterans Administration, USPHS Grant AA-02054 and the Geriatric Research, Education, and Clinical Center of the St. Louis Veterans Administration Medical Center. The authors gratefully acknowledge the excellent secretarial assistance of Cheryl Mason.",

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T1 - Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

AU - Gibson Wood, W.

AU - Gorka, Christine

AU - James Armbrecht, H.

AU - Williamson, Lisa S.

AU - Strong, Randy

N1 - Funding Information: This work was supported by the Medical Research Service of the Veterans Administration, USPHS Grant AA-02054 and the Geriatric Research, Education, and Clinical Center of the St. Louis Veterans Administration Medical Center. The authors gratefully acknowledge the excellent secretarial assistance of Cheryl Mason.

PY - 1986/12/1

Y1 - 1986/12/1

N2 - This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.

AB - This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.

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DO - 10.1016/0024-3205(86)90360-7

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JO - Life Sciences

JF - Life Sciences

IS - 22

ER -

Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

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ASJC Scopus subject areas

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