TY - JOUR
T1 - First detection of TR34 L98H and TR46 Y121F T289A Cyp51 mutations in aspergillus fumigatus isolates in the United States
AU - Wiederhold, Nathan P.
AU - Gil, Veronica Garcia
AU - Gutierrez, Felipe
AU - Lindner, Jonathan R.
AU - Albataineh, Mohammad T.
AU - McCarthy, Dora I.
AU - Sanders, Carmita
AU - Fan, Hongxin
AU - Fothergill, Annette W.
AU - Sutton, Deanna A.
N1 - Publisher Copyright:
© 2015, American Society for Microbiology. All Rights Reserved.
PY - 2016/1
Y1 - 2016/1
N2 - Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.
AB - Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.
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U2 - 10.1128/JCM.02478-15
DO - 10.1128/JCM.02478-15
M3 - Article
C2 - 26491179
AN - SCOPUS:84954310847
SN - 0095-1137
VL - 54
SP - 168
EP - 171
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 1
ER -