First approved inhaled insulin therapy for diabetes mellitus

Rucha Jani, Curtis Triplitt, Charles Reasner, Ralph Albarado DeFronzo

Resultado de la investigación: Articlerevisión exhaustiva

16 Citas (Scopus)


The long-term benefits of tight glycemic control in preventing microvascular and macrovascular complications are well established in both Type 1 diabetes mellitus (Type 1 DM) and Type 2 diabetes mellitus (Type 2 DM). Nonetheless, achievement of recommended haemoglobin A1c (HbA1c) goals (≤ 6.5 - 7.0%) has remained elusive, especially in patients with diabetes who require insulin therapy. Delayed/suboptimal titration of insulin is partly related to poor acceptance of multiple injection regimen by both physicians and patients. EXUBERA® (human insulin [rDNA origin]; Pfizer), the first approved inhaled insulin for the treatment of diabetic patients, has been shown to be safe and as effective as regular/rapidly acting insulin in improving glycemic control. In addition to controlling postprandial glucose excursions, EXUBERA exerts a major action to reduce fasting plasma glucose (FPG) concentration. Thus, it has the potential to be used as a monotherapy in Type 2 DM, as well as in combination with an insulin sensitizer in Type 2 DM or in combination with long-acting insulin in both Type 2 DM and Type 1 DM.

Idioma originalEnglish (US)
Páginas (desde-hasta)63-76
Número de páginas14
PublicaciónExpert Opinion on Drug Delivery
EstadoPublished - ene 2007

ASJC Scopus subject areas

  • Pharmaceutical Science


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