Fibrinolysis resistance after liver transplant as a predictor of early infection

Ivan E. Rodriguez, Dor Yoeli, Tanner Ferrell, Jessie G. Jiang, Ronald Truong, Trevor L. Nydam, Megan A. Adams, J. Michael Cullen, Elizabeth A. Pomfret, Hunter B. Moore

Producción científica: Articlerevisión exhaustiva

2 Citas (Scopus)


Background: Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection. Methods: Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR. FR was defined as LY30 = 0% and stratified as transient if present on POD1 or POD5 (tFR), persistent (pFR) if present on both, or no FR (nFR) if absent. Results: 180 LT recipients were prospectively enrolled. 52 (29%) recipients developed infection. 72 had tFR; 37 had pFR; and 71 had nFR. Recipients with pFR had significantly greater incidence of infections (51% vs. 26% tFR vs. 20% nFR, p = 0.002). pFR was independently associated with increased odds of post-transplant infection (adjusted OR 3.39, p = 0.009). Conclusions: Persistent fibrinolysis resistance is associated with increased risk of post-transplant infection.

Idioma originalEnglish (US)
Páginas (desde-hasta)1455-1459
Número de páginas5
PublicaciónAmerican journal of surgery
EstadoPublished - dic 2022
Publicado de forma externa

ASJC Scopus subject areas

  • Surgery


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