TY - JOUR
T1 - Fibrinogen
T2 - Structure, function, and surface interactions
AU - Fuss, C.
AU - Palmaz, J. C.
AU - Sprague, E. A.
PY - 2001
Y1 - 2001
N2 - Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α116,β3 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.
AB - Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α116,β3 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.
KW - Anticoagulant
KW - Fibrinogen
UR - http://www.scopus.com/inward/record.url?scp=0035006002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035006002&partnerID=8YFLogxK
U2 - 10.1016/S1051-0443(07)61437-7
DO - 10.1016/S1051-0443(07)61437-7
M3 - Review article
C2 - 11389218
AN - SCOPUS:0035006002
SN - 1051-0443
VL - 12
SP - 677
EP - 682
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 6
ER -