Fibrinogen: Structure, function, and surface interactions

Producción científica: Review articlerevisión exhaustiva

127 Citas (Scopus)

Resumen

Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α1163 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

Idioma originalEnglish (US)
Páginas (desde-hasta)677-682
Número de páginas6
PublicaciónJournal of Vascular and Interventional Radiology
Volumen12
N.º6
DOI
EstadoPublished - 2001

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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