@inproceedings{96998dde80f94b62b7ee808c0bffbcd2,
title = "Fiber optic fluorescence microscopy for functional brain imaging in awake, mobile mice",
abstract = "Fiber-optic based optical imaging is an emerging technique for studying brain activity in live animals. Here, we introduce a novel fluorescence fiber-optic microendoscopy approach to minimal invasively detect neural activities in a live mouse brain. The system uses a flexible endoscopic probe composed of a multi-core coherent fiber-bundle terminated with an approximately 1500-micron working distance objective lens. The fiber-optic neural interface is mounted on a 4-mm2 cranial window enabling visualization of glial calcium transients from the same brain region for weeks. We evaluated the system performance through in vivo imaging of GCaMP3 fluorescence in transgenic headrestrained mice during locomotion.",
keywords = "Astrocyte calcium transients, Fiber-optic sensor, Fluorescence microendoscopy, Functional brain imaging, GCaMP3, cerebellum",
author = "Jaepyeong Cha and Martin Paukert and Bergles, {Dwight E.} and Kang, {Jin U.}",
year = "2014",
doi = "10.1117/12.2038265",
language = "English (US)",
isbn = "9780819498410",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics",
note = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics ; Conference date: 01-02-2014 Through 04-02-2014",
}