Familial translocation t(10;14) (q26.1;q32.3): report of three offspring with 10q deletion and 14q duplication

Tim H.‐M Huang, Diane Peckham, Jacqueline R. Batanian, Matthew B. Martin, Melissa Kouba, Charles W. Caldwell, Judith H. Miles

Resultado de la investigación: Articlerevisión exhaustiva

4 Citas (Scopus)

Resumen

We describe two brothers and a cousin with common clinical features, including mild mental retardation, motor delays, hypotonia with truncal ataxia, esotropia, and mild facial and hand dysmorphia. The initial routine chromosome study failed to detect any abnormality in the proband. Based on a high index of clinical suspicion, high‐resolution chromosome studies were performed on the proband's parents. A small reciprocal translocation t(10;14) (q26.1;q32.3) was detected in the father. The breakpoint on the derivative chromosome 14 was further placed telomeric to the immunoglobulin heavy‐chain gene cluster at the band q32.33 by fluorescence in situ hybridization. Studies of the proband and two affected paternal cousins revealed that each had inherited the same derivative chromosome 10 from their carrier parents. This unbalanced karyotype resulted from an adjacent‐1 segregation of the 10;14 translocation.

Idioma originalEnglish (US)
Páginas (desde-hasta)299-303
Número de páginas5
PublicaciónClinical Genetics
Volumen46
N.º4
DOI
EstadoPublished - oct. 1994
Publicado de forma externa

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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