TY - JOUR
T1 - Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice
AU - Strong, Randy
AU - Nelson, James F.
AU - Bogue, Molly A.
AU - Colca, Jerry R.
AU - Denzel, Martin
AU - Diaz, Vivian
AU - Finck, Brian N.
AU - Gladyshev, Vadim N.
AU - Horvath, Steve
AU - Jiang, Nisi
AU - Keller, Tracy
AU - Kletzien, Rolf F.
AU - Korstanje, Ron
AU - Kumar, Navasuja
AU - Leeuwenburgh, Christiaan
AU - Fernandez, Elizabeth
AU - Galecki, Andrzej
AU - Ginsburg, Brett
AU - Han, Melissa
AU - Kaczorowski, Catherine
AU - Leiser, Scott
AU - Lopez-Cruzan, Marisa
AU - Raj, Ken
AU - Reifsnyder, Peter C.
AU - Rosenthal, Nadia A.
AU - Rosi, Susanna
AU - Shindyapina, Anastasia
AU - Stacpoole, Peter
AU - Salmon, Adam B.
AU - Tyshkovskiy, Alexander
AU - Walter, Peter
AU - Whitman, Malcolm
AU - Miller, Richard A.
AU - Harrison, David E.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2026/6
Y1 - 2026/6
N2 - Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.
AB - Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.
KW - Epicatechin
KW - Genetically heterogeneous mice
KW - Halofuginone
KW - Mitoglitazone
KW - Survival
UR - https://www.scopus.com/pages/publications/105016764122
UR - https://www.scopus.com/pages/publications/105016764122#tab=citedBy
U2 - 10.1007/s11357-025-01881-6
DO - 10.1007/s11357-025-01881-6
M3 - Article
C2 - 40973907
AN - SCOPUS:105016764122
SN - 2509-2715
VL - 48
SP - 4139
EP - 4156
JO - GeroScience
JF - GeroScience
IS - 3
ER -