Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid

Charles M. Nolan; Robert A. Clark; Harry N. Beaty

doi:10.3181/00379727-150-38989

Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid

Charles M. Nolan, Robert A. Clark, Harry N. Beaty

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Resumen

Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

Idioma original	English (US)
Páginas (desde-hasta)	134-136
Número de páginas	3
Publicación	Proceedings of the Society for Experimental Biology and Medicine
Volumen	150
N.º	1
DOI	https://doi.org/10.3181/00379727-150-38989
Estado	Published - oct 1975
Publicado de forma externa	Sí

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid",

abstract = "Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.",

author = "Nolan, {Charles M.} and Clark, {Robert A.} and Beaty, {Harry N.}",

note = "Funding Information: This work was supported by Grants CC00665 and AI03456 from the Center for Disease Control and the National Institute of Allergy and Infectious Disease. ",

year = "1975",

month = oct,

doi = "10.3181/00379727-150-38989",

language = "English (US)",

volume = "150",

pages = "134--136",

journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",

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AU - Nolan, Charles M.

AU - Clark, Robert A.

AU - Beaty, Harry N.

N1 - Funding Information: This work was supported by Grants CC00665 and AI03456 from the Center for Disease Control and the National Institute of Allergy and Infectious Disease.

PY - 1975/10

Y1 - 1975/10

N2 - Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

AB - Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

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SN - 1535-3702

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Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid

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