Exotic mice for aging: Authors' reply

Richard A. Miller, David Burke, Steve Austad

Resultado de la investigación: Comment/debaterevisión exhaustiva


The authors reply here to comments made by Drs. McClearn and Festing about the strengths and weaknesses of nonstandard mouse models in experimental gerontology, stressing once again the trade-off between internal and external validity. Although the use of genetically isogenic mice may, in some cases, minimize experimental costs by diminishing variance among individuals, reliance on a small number of inbred, long-domesticated stocks diminishes the external validity of a research program, i.e., the degree to which its conclusions give insights into questions of greater biological interest than the behavior of a single genotype.

Idioma originalEnglish (US)
Páginas (desde-hasta)245-246
Número de páginas2
PublicaciónNeurobiology of Aging
EstadoPublished - ene 1 1999

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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