Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

Brian P. Rubin; Koichi Nishijo; Hung I.Harry Chen; Xiaolan Yi; David P. Schuetze; Ranadip Pal; Suresh I. Prajapati; Jinu Abraham; Benjamin R. Arenkiel; Qing Rong Chen; Sean Davis; Amanda T. McCleish; Mario R. Capecchi; Joel E. Michalek; Lee Ann Zarzabal; Javed Khan; Zhongxin Yu; David M. Parham; Frederic G. Barr; Paul S. Meltzer; Yidong Chen; Charles Keller

doi:10.1016/j.ccr.2010.12.023

Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

Brian P. Rubin, Koichi Nishijo, Hung I.Harry Chen, Xiaolan Yi, David P. Schuetze, Ranadip Pal, Suresh I. Prajapati, Jinu Abraham, Benjamin R. Arenkiel, Qing Rong Chen, Sean Davis, Amanda T. McCleish, Mario R. Capecchi, Joel E. Michalek, Lee Ann Zarzabal, Javed Khan, Zhongxin Yu, David M. Parham, Frederic G. Barr, Paul S. MeltzerYidong Chen, Charles Keller

Producción científica: Article › revisión exhaustiva

149 Citas (Scopus)

Resumen

Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS. Conversely, p53 loss in maturing myoblasts gives rise to eRMS, which have the highest myodifferentiation potential. Regardless of origin, Rb1 loss modifies tumor phenotype to mimic UPS. In human sarcomas that lack pathognomic chromosomal translocations, p53 loss of function is prevalent, whereas Shh or Rb1 alterations likely act primarily as modifiers. Thus, sarcoma phenotype is strongly influenced by cell of origin and mutational profile.

Idioma original	English (US)
Páginas (desde-hasta)	177-191
Número de páginas	15
Publicación	Cancer Cell
Volumen	19
N.º	2
DOI	https://doi.org/10.1016/j.ccr.2010.12.023
Estado	Published - feb 15 2011

ASJC Scopus subject areas

Oncology
Cancer Research

Acceder al documento

10.1016/j.ccr.2010.12.023

Otros archivos y enlaces

Citar esto

Rubin, B. P., Nishijo, K., Chen, H. I. H., Yi, X., Schuetze, D. P., Pal, R., Prajapati, S. I., Abraham, J., Arenkiel, B. R., Chen, Q. R., Davis, S., McCleish, A. T., Capecchi, M. R., Michalek, J. E., Zarzabal, L. A., Khan, J., Yu, Z., Parham, D. M., Barr, F. G., ... Keller, C. (2011). Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma. Cancer Cell, 19(2), 177-191. https://doi.org/10.1016/j.ccr.2010.12.023

Rubin, BP, Nishijo, K, Chen, HIH, Yi, X, Schuetze, DP, Pal, R, Prajapati, SI, Abraham, J, Arenkiel, BR, Chen, QR, Davis, S, McCleish, AT, Capecchi, MR, Michalek, JE, Zarzabal, LA, Khan, J, Yu, Z, Parham, DM, Barr, FG, Meltzer, PS, Chen, Y & Keller, C 2011, 'Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma', Cancer Cell, vol. 19, n.º 2, pp. 177-191. https://doi.org/10.1016/j.ccr.2010.12.023

@article{330db2c9d58b476288c4f091374be1fe,

title = "Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma",

abstract = "Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS. Conversely, p53 loss in maturing myoblasts gives rise to eRMS, which have the highest myodifferentiation potential. Regardless of origin, Rb1 loss modifies tumor phenotype to mimic UPS. In human sarcomas that lack pathognomic chromosomal translocations, p53 loss of function is prevalent, whereas Shh or Rb1 alterations likely act primarily as modifiers. Thus, sarcoma phenotype is strongly influenced by cell of origin and mutational profile.",

author = "Rubin, {Brian P.} and Koichi Nishijo and Chen, {Hung I.Harry} and Xiaolan Yi and Schuetze, {David P.} and Ranadip Pal and Prajapati, {Suresh I.} and Jinu Abraham and Arenkiel, {Benjamin R.} and Chen, {Qing Rong} and Sean Davis and McCleish, {Amanda T.} and Capecchi, {Mario R.} and Michalek, {Joel E.} and Zarzabal, {Lee Ann} and Javed Khan and Zhongxin Yu and Parham, {David M.} and Barr, {Frederic G.} and Meltzer, {Paul S.} and Yidong Chen and Charles Keller",

note = "Funding Information: Trainee and research support was provided by the Scott Carter Foundation as well K99NS064171-02 and 5R01CA133229-04. Human tissue samples were provided by the NCI-supported Cooperative Human Tissue Network. The NICHD-supported DSHB is maintained by The University of Iowa. Authors thank Maricela Castillo for technical assistance. ",

year = "2011",

month = feb,

day = "15",

doi = "10.1016/j.ccr.2010.12.023",

language = "English (US)",

volume = "19",

pages = "177--191",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

AU - Rubin, Brian P.

AU - Nishijo, Koichi

AU - Chen, Hung I.Harry

AU - Yi, Xiaolan

AU - Schuetze, David P.

AU - Pal, Ranadip

AU - Prajapati, Suresh I.

AU - Abraham, Jinu

AU - Arenkiel, Benjamin R.

AU - Chen, Qing Rong

AU - Davis, Sean

AU - McCleish, Amanda T.

AU - Capecchi, Mario R.

AU - Michalek, Joel E.

AU - Zarzabal, Lee Ann

AU - Khan, Javed

AU - Yu, Zhongxin

AU - Parham, David M.

AU - Barr, Frederic G.

AU - Meltzer, Paul S.

AU - Chen, Yidong

AU - Keller, Charles

N1 - Funding Information: Trainee and research support was provided by the Scott Carter Foundation as well K99NS064171-02 and 5R01CA133229-04. Human tissue samples were provided by the NCI-supported Cooperative Human Tissue Network. The NICHD-supported DSHB is maintained by The University of Iowa. Authors thank Maricela Castillo for technical assistance.

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS. Conversely, p53 loss in maturing myoblasts gives rise to eRMS, which have the highest myodifferentiation potential. Regardless of origin, Rb1 loss modifies tumor phenotype to mimic UPS. In human sarcomas that lack pathognomic chromosomal translocations, p53 loss of function is prevalent, whereas Shh or Rb1 alterations likely act primarily as modifiers. Thus, sarcoma phenotype is strongly influenced by cell of origin and mutational profile.

AB - Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS. Conversely, p53 loss in maturing myoblasts gives rise to eRMS, which have the highest myodifferentiation potential. Regardless of origin, Rb1 loss modifies tumor phenotype to mimic UPS. In human sarcomas that lack pathognomic chromosomal translocations, p53 loss of function is prevalent, whereas Shh or Rb1 alterations likely act primarily as modifiers. Thus, sarcoma phenotype is strongly influenced by cell of origin and mutational profile.

UR - http://www.scopus.com/inward/record.url?scp=79751484162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79751484162&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2010.12.023

DO - 10.1016/j.ccr.2010.12.023

M3 - Article

C2 - 21316601

AN - SCOPUS:79751484162

SN - 1535-6108

VL - 19

SP - 177

EP - 191

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -

Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto