Everolimus for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC)

Hani M. Babiker, Michael Karass, Alejandro Recio-Boiles, Sreenivasa R. Chandana, Ali McBride, Daruka Mahadevan

Producción científica: Articlerevisión exhaustiva

17 Citas (Scopus)

Resumen

Introduction: PDAC is a lethal malignancy with a clear unmet need; almost all patients fail 1st, 2nd, and 3rd line multi-agent cytotoxic chemotherapy. The mammalian target of rapamycin (mTOR) has been identified as a key signaling node enhancing tumor survival and drug resistance in PDAC; hence, it is considered a promising therapeutic target. Areas covered: We comprehensively reviewed the evidence from preclinical and phase I and II clinical trials, based on the authors’clinical experience and a PubMed, Cochrane library, Embase, and Google Scholar search everolimus + pancreatic cancer. Expert opinion: Everolimus has not demonstrated efficacy in PDAC; however, an mTOR inhibitor in combination with stroma-targeted therapies may be a promising area to explore in clinical trials.

Idioma originalEnglish (US)
Páginas (desde-hasta)583-592
Número de páginas10
PublicaciónExpert Opinion on Investigational Drugs
Volumen28
N.º7
DOI
EstadoPublished - jul 3 2019
Publicado de forma externa

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Huella

Profundice en los temas de investigación de 'Everolimus for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC)'. En conjunto forman una huella única.

Citar esto