Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF

Ai Ling Lin, Peter T. Fox, Yihong Yang, Hanzhang Lu, Li Hai Tan, Jia Hong Gao

Producción científica: Articlerevisión exhaustiva

68 Citas (Scopus)


The aim of this study was to investigate the various MRI biophysical models in the measurements of local cerebral metabolic rate of oxygen (CMRO 2) and the corresponding relationship with cerebral blood flow (CBF) during brain activation. This aim was addressed by simultaneously measuring the relative changes in CBF, cerebral blood volume (CBV), and blood oxygen level dependent (BOLD) MRI signals in the human visual cortex during visual stimulation. A radial checkerboard delivered flash stimulation at five different frequencies. Two MRI models, the single-compartment model (SCM) and the multicompartment model (MCM), were used to determine the relative changes in CMRO2 using three methods: [1] SCM with parameters identical to those used in a prior MRI study (M = 0.22; α = 0.38); [2] SCM with directly measured parameters (M from hypercapnia and α from measured δCBV and δCBF); and [3] MCM. The magnitude of relative changes in CMRO2 and the nonlinear relationship between CBF and CMRO2 obtained with Methods [2] and [3] were not in agreement with those obtained using Method [1]. However, the results of Methods [2] and [3] were aligned with positron emission tomography findings from the literature. Our results indicate that if appropriate parameters are used, the SCM and MCM models are equivalent for quantifying the values of CMRO2 and determining the flow-metabolism relationship.

Idioma originalEnglish (US)
Páginas (desde-hasta)380-389
Número de páginas10
PublicaciónMagnetic Resonance in Medicine
EstadoPublished - ago 2008

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Profundice en los temas de investigación de 'Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF'. En conjunto forman una huella única.

Citar esto