ESCRTing Necroptosis

Hongyan Guo; William J. Kaiser

doi:10.1016/j.cell.2017.03.030

ESCRTing Necroptosis

Hongyan Guo, William J. Kaiser

Department of Microbiology, Immunology & Molecular Genetics

Resultado de la investigación: Short survey › revisión exhaustiva

7 Citas (Scopus)

Resumen

Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.

Idioma original	English (US)
Páginas (desde-hasta)	186-187
Número de páginas	2
Publicación	Cell
Volumen	169
N.º	2
DOI	https://doi.org/10.1016/j.cell.2017.03.030
Estado	Published - abr. 6 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2017.03.030

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title = "ESCRTing Necroptosis",

abstract = "Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.",

author = "Hongyan Guo and Kaiser, {William J.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratory is supported by funding from the NIH (DP5 OD012198) and the William and Ella Owens Medical Research Foundation. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

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AU - Guo, Hongyan

AU - Kaiser, William J.

N1 - Funding Information: Work in the authors’ laboratory is supported by funding from the NIH (DP5 OD012198) and the William and Ella Owens Medical Research Foundation. Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/4/6

Y1 - 2017/4/6

N2 - Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.

AB - Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.

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ESCRTing Necroptosis

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ASJC Scopus subject areas

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