TY - JOUR
T1 - Escape of human immunodeficiency virus type 1 from broadly neutralizing antibodies is not associated with a reduction of viral replicative capacity in vitro
AU - Quakkelaar, Esther D.
AU - Bunnik, Evelien M.
AU - van Alphen, Floris P.J.
AU - Boeser-Nunnink, Brigitte D.M.
AU - van Nuenen, Ad C.
AU - Schuitemaker, Hanneke
N1 - Funding Information:
This study is supported financially by the Dutch AIDS Fund, grants 7009 and 2004064.
Funding Information:
The Amsterdam Cohort Studies on HIV infection and AIDS, a collaboration between the Amsterdam Health Service, the Amsterdam Medical Center of the University of Amsterdam, Sanquin Blood Supply Foundation and the University Medical Center Utrecht, are part of The Netherlands HIV Monitoring Foundation and financially supported by The Netherlands National Institute for Public Health and the Environment.
PY - 2007/7/5
Y1 - 2007/7/5
N2 - Although the majority of primary HIV-1 variants can be neutralized by broadly neutralizing antibodies such as b12, 2G12, 2F5 and 4E10, resistance to these antibodies has been reported as well. The ability of the broadly neutralizing antibodies to inhibit a variety of viruses suggests that their epitopes are conserved and escape from these antibodies may thus come at a cost to viral fitness. Here we demonstrate that resistance to broadly neutralizing antibodies was in general not associated with a reduced replicative capacity of the virus in vitro. This indicates that loss of replicative capacity due to escape from broadly neutralizing antibodies may be limited.
AB - Although the majority of primary HIV-1 variants can be neutralized by broadly neutralizing antibodies such as b12, 2G12, 2F5 and 4E10, resistance to these antibodies has been reported as well. The ability of the broadly neutralizing antibodies to inhibit a variety of viruses suggests that their epitopes are conserved and escape from these antibodies may thus come at a cost to viral fitness. Here we demonstrate that resistance to broadly neutralizing antibodies was in general not associated with a reduced replicative capacity of the virus in vitro. This indicates that loss of replicative capacity due to escape from broadly neutralizing antibodies may be limited.
KW - Broadly neutralizing antibodies
KW - Escape
KW - HIV-1
KW - Replicative capacity
UR - https://www.scopus.com/pages/publications/34249029693
UR - https://www.scopus.com/pages/publications/34249029693#tab=citedBy
U2 - 10.1016/j.virol.2007.02.011
DO - 10.1016/j.virol.2007.02.011
M3 - Article
C2 - 17355886
AN - SCOPUS:34249029693
SN - 0042-6822
VL - 363
SP - 447
EP - 453
JO - Virology
JF - Virology
IS - 2
ER -