Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Laurence Morel

doi:10.1016/j.it.2021.10.010

Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Laurence Morel

Producción científica: Short survey › revisión exhaustiva

5 Citas (Scopus)

Resumen

Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.

Idioma original	English (US)
Páginas (desde-hasta)	1054-1056
Número de páginas	3
Publicación	Trends in Immunology
Volumen	42
N.º	12
DOI	https://doi.org/10.1016/j.it.2021.10.010
Estado	Published - dic 2021
Publicado de forma externa	Sí

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.it.2021.10.010

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title = "Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus",

abstract = "Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.",

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Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

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Huella

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