Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Denis Feliers

doi:10.1038/ki.2015.224

Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Denis Feliers

Department of Medicine

Resultado de la investigación: Comment/debate › revisión exhaustiva

6 Citas (Scopus)

Resumen

Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

Idioma original	English (US)
Páginas (desde-hasta)	668-670
Número de páginas	3
Publicación	Kidney international
Volumen	88
N.º	4
DOI	https://doi.org/10.1038/ki.2015.224
Estado	Published - oct 3 2015

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2015.224

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abstract = "Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.",

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Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Resumen

ASJC Scopus subject areas

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