Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment

Amy M. Dworkin, Tim H.M. Huang, Amanda Ewart Toland

Producción científica: Review articlerevisión exhaustiva

140 Citas (Scopus)

Resumen

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics because of their potential for reversal. Future medical care for breast cancer patients will likely depend upon a better understanding of the roles epigenetic modifications play in carcinogenesis. Here, we discuss the importance of epigenetics in breast cancer detection, prognosis, and therapy with an emphasis on mechanisms and epigenetic contributions to field cancerization effects.

Idioma originalEnglish (US)
Páginas (desde-hasta)165-171
Número de páginas7
PublicaciónSeminars in Cancer Biology
Volumen19
N.º3
DOI
EstadoPublished - jun 2009
Publicado de forma externa

ASJC Scopus subject areas

  • Cancer Research

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