Eosinophilic bronchitis-like lesion as the cause of death in a Macaca mulatta: A first case report

J. L. Christal, G. B. Hubbard, E. J. Dick, K. M. Brasky, Jaishree Jagirdar

Resultado de la investigación: Articlerevisión exhaustiva

3 Citas (Scopus)


Background: Eosinophilic bronchitis is a recently described, relatively benign condition in humans that is characterized by a corticosteroid-responsive chronic cough and sputum eosinophilia without the abnormalities of airway function seen in asthma. The exact cause of this condition is currently unknown, however has been associated with various occupational exposures in humans. It has also been reported to progress to irreversible airway obstruction. This disease has been reported in dogs and horses, but not in non-human primates. Methods: Gross examination of an otherwise healthy 13-year-old, colony-born Macaca mulatta, which died of severe non-responsive respiratory distress revealed that the lungs were markedly inflated and moist. Results: Hematoxylin and eosin-stained sections from the lungs contained widespread accumulation of eosinophils, sloughed epithelial cells, and mucus centered around bronchioles and adjacent airways. There was no evidence of mast cell infiltration of peribronchiolar smooth muscle, goblet cell hyperplasia, or basement membrane thickening. Conclusions: This ruled out recurrent episodes as would be expected in asthma, favoring the diagnosis of an eosinophilic bronchitis-like lesion. We report a first case of eosinophilic bronchitis-like features in a M. mulatta.

Idioma originalEnglish (US)
Páginas (desde-hasta)63-66
Número de páginas4
PublicaciónJournal of medical primatology
EstadoPublished - abr 2008

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


Profundice en los temas de investigación de 'Eosinophilic bronchitis-like lesion as the cause of death in a Macaca mulatta: A first case report'. En conjunto forman una huella única.

Citar esto