Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MCSGs) in allosensitized rats. Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts. MCSGs and control allografts were covered with either Vaseline gauze (VG) or SN; direct current, 40 μA, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed. SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks. VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months. Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008). MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft. Conclusions: SN dressings enhanced survival of meshed composite skin grafts.
|Idioma original||English (US)|
|Número de páginas||6|
|Publicación||Journal of Trauma - Injury, Infection and Critical Care|
|Estado||Published - 1995|
|Publicado de forma externa||Sí|
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine