Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline

Liuji Chen, Ren Na, Qitao Ran

Producción científica: Articlerevisión exhaustiva

31 Citas (Scopus)

Resumen

Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition between aged (17-19months) APP transgenic mice and APP/Prdx3 double transgenic mice (dTG) and between old (24months) wild-type mice and Prdx3 transgenic mice (TG). Compared with aged APP mice, aged dTG mice showed improved cognition that was correlated with reduced brain amyloid beta levels and decreased amyloid beta production. Old TG mice also showed significantly increased cognitive ability compared with old wild-type mice. Both aged dTG mice and old TG mice had reduced mitochondrial oxidative stress and increased mitochondrial function. Moreover, CREB signaling, a signaling pathway important for cognition was enhanced in both aged dTG mice and old TG mice. Thus, our results indicate that mitochondrial H2O2 is a key culprit of age-associated cognitive impairment, and that a reduction of mitochondrial H2O2 could improve cognition by maintaining mitochondrial health and enhancing CREB signaling.

Idioma originalEnglish (US)
Páginas (desde-hasta)2552-2561
Número de páginas10
PublicaciónNeurobiology of Aging
Volumen35
N.º11
DOI
EstadoPublished - nov 1 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • General Neuroscience
  • Developmental Biology

Huella

Profundice en los temas de investigación de 'Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline'. En conjunto forman una huella única.

Citar esto