TY - JOUR
T1 - Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism
T2 - Implications for Therapy
AU - Sukhovershin, Roman A.
AU - Yepuri, Gautham
AU - Ghebremariam, Yohannes T.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.
AB - Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.
KW - antiatherogenic
KW - asymmetric dimethylarginine
KW - atherosclerosis
KW - dimethylarginine dimethylaminohydrolase
KW - endothelial nitric oxide synthase
KW - endothelium
KW - nitric oxide
KW - vascular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85015987494&partnerID=8YFLogxK
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U2 - 10.14797/mdcj-11-3-166
DO - 10.14797/mdcj-11-3-166
M3 - Review article
C2 - 26634024
AN - SCOPUS:85015987494
SN - 1947-6094
VL - 11
SP - 166
EP - 171
JO - Methodist DeBakey cardiovascular journal
JF - Methodist DeBakey cardiovascular journal
IS - 3
ER -