TY - JOUR
T1 - Endothelial Nicotinic Acetylcholine Receptors and Angiogenesis
AU - Cooke, John P.
AU - Ghebremariam, Yohannes T.
N1 - Funding Information:
This study was supported by grants from the National Institutes of Health (Bethesda, MD, RO1 HL-75774, RO1 CA098303, R21 HL085743, 1K12 HL087746), the California Tobacco Related Disease Research Program of the University of California (Oakland, CA, 15IT-0257 and 1514RT-0169), and the California Institute for Regenerative Medicine (San Francisco, RS1-00183).
PY - 2008/10
Y1 - 2008/10
N2 - Nicotinic acetylcholine receptors (nAChRs) were first described in non-excitable cells just more than a decade ago. The nAChRs on endothelial cells modulate key angiogenic processes, including endothelial cell survival, proliferation, and migration. The receptors may be stimulated by endogenous agonists such as acetylcholine, or exogenous chemicals such as nicotine, to activate physiologic angiogenesis (such as in wound healing) or pathologic angiogenesis (such as retinal neovascularization or tumor angiogenesis). The endothelial nAChRs may represent a target for therapeutic modulation of disorders characterized by insufficient or pathologic angiogenesis.
AB - Nicotinic acetylcholine receptors (nAChRs) were first described in non-excitable cells just more than a decade ago. The nAChRs on endothelial cells modulate key angiogenic processes, including endothelial cell survival, proliferation, and migration. The receptors may be stimulated by endogenous agonists such as acetylcholine, or exogenous chemicals such as nicotine, to activate physiologic angiogenesis (such as in wound healing) or pathologic angiogenesis (such as retinal neovascularization or tumor angiogenesis). The endothelial nAChRs may represent a target for therapeutic modulation of disorders characterized by insufficient or pathologic angiogenesis.
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U2 - 10.1016/j.tcm.2008.11.007
DO - 10.1016/j.tcm.2008.11.007
M3 - Review article
C2 - 19232953
AN - SCOPUS:60149109178
SN - 1050-1738
VL - 18
SP - 247
EP - 253
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 7
ER -