Endothelial function and the regulation of muscle protein anabolism in older adults

K. L. Timmerman, E. Volpi

Producción científica: Review articlerevisión exhaustiva

39 Citas (Scopus)


Sarcopenia, the loss of skeletal muscle mass and function with aging, is a major contributor to frailty and morbidity in older adults. Recent evidence has emerged suggesting that endothelial dysfunction and insulin resistance of muscle protein metabolism may significantly contribute to the development of sarcopenia. In this article we review: 1) recent studies and theories on the regulation of skeletal muscle protein balance in older adults; 2) the linkbetween insulin resistance of muscle protein synthesis and endothelial dysfunction in aging; 3) mechanisms for impaired endothelial responsiveness in aging; and 4) potential treatments that may restore the endothelial responsiveness and muscle protein anabolic sensitivity in older adults.

Idioma originalEnglish (US)
Páginas (desde-hasta)S44eS50
PublicaciónNutrition, Metabolism and Cardiovascular Diseases
EstadoPublished - 2013
Publicado de forma externa

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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