Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa

Marta Sanchis, Deanna A. Sutton, Nathan P. Wiederhold, Josep Guarro, Javier Capilla

Producción científica: Articlerevisión exhaustiva

2 Citas (Scopus)


Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.

Idioma originalEnglish (US)
Páginas (desde-hasta)61-65
Número de páginas5
PublicaciónDiagnostic Microbiology and Infectious Disease
EstadoPublished - sept 1 2016

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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