TY - JOUR
T1 - Effects of thiamin deficiency on acetylcholine levels and utilization in vivo in rat brain
AU - Vorhees, C. V.
AU - Schmidt, D. E.
AU - Barrett, R. J.
AU - Schenker, S.
PY - 1977
Y1 - 1977
N2 - Cerebral regional acetylcholine (ACh) levels and utilization were studied in vivo in thiamin deficient (TD), pair-fed asymptomatic (PFC) and ad libitum fed control (ALC) rats. ACh levels in the cortex, corpus striatum, midbrain, diencephalon and brainstem of TD rats were comparable to those observed in the control groups. However, ACh utilization was slightly to moderately (10-41%) decreased in cortex, midbrain, diencephalon and brainstem. The decrease was significantly different in the midbrain of TD rats as compared to PFC and ALC rats.
AB - Cerebral regional acetylcholine (ACh) levels and utilization were studied in vivo in thiamin deficient (TD), pair-fed asymptomatic (PFC) and ad libitum fed control (ALC) rats. ACh levels in the cortex, corpus striatum, midbrain, diencephalon and brainstem of TD rats were comparable to those observed in the control groups. However, ACh utilization was slightly to moderately (10-41%) decreased in cortex, midbrain, diencephalon and brainstem. The decrease was significantly different in the midbrain of TD rats as compared to PFC and ALC rats.
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U2 - 10.1093/jn/107.10.1902
DO - 10.1093/jn/107.10.1902
M3 - Article
C2 - 903833
AN - SCOPUS:0017670299
VL - 107
SP - 1902
EP - 1908
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 10
ER -