Effects of selective hepatic vagotomy on running endurance in rats

B. Doiron, S. Cardin, G. R. Brisson, J. M. Lavoie

Resultado de la investigación: Articlerevisión exhaustiva

4 Citas (Scopus)


The liver, through the afferent ways of the vagus hepatic nerve, may influence metabolic adaptations during exercise. This study assesses the functional significance of this hepatic innervation by determining the effect of a selective hepatic vagotomy (HV) on running endurance time during submaximal activity in rats subjected to an overnight 50% food restriction. The time to exhaustion was similar for the groups of HV and sham-operated (SHM) rats [66 ± 15 vs. 64 ± 21 (SD) min]. The HV group was associated with higher resting levels (P < 0.05) of hepatic glycogen and plasma glucose. No significant differences were observed between HV and SHM rats at rest and after exercise for muscle glycogen, free fatty acids, insulin, glucagon, and lactate concentrations. These data indicate that if hepatic glucoreceptors do exist and contribute to the metabolic regulation of exercise, their functional significance is secondary to more important regulatory mechanisms.

Idioma originalEnglish (US)
Páginas (desde-hasta)2197-2201
Número de páginas5
PublicaciónJournal of applied physiology
EstadoPublished - 1990
Publicado de forma externa

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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