TY - JOUR
T1 - Effects of ethanol on acetylcholine and GABA release
T2 - differences in the role of potassium.
AU - Strong, R.
AU - Rehwaldt, C.
AU - Wood, W. G.
AU - Sun, A. Y.
AU - Sun, G. Y.
PY - 1987
Y1 - 1987
N2 - Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.
AB - Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.
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M3 - Article
C2 - 3426745
AN - SCOPUS:0023461636
SN - 1358-6173
VL - 1
SP - 631
EP - 635
JO - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.
JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.
ER -