Effects of a maternal low protein isocaloric diet on milk leptin and progeny serum leptin concentration and appetitive behavior in the first 21 days of neonatal life in the rat

Claudia J. Bautista, Lourdes Boeck, Fernando Larrea, Peter W. Nathanielsz, Elena Zambrano

Resultado de la investigación: Articlerevisión exhaustiva

66 Citas (Scopus)

Resumen

Suboptimal developmental environments program offspring to lifelong metabolic problems. We evaluated effects of maternal isocaloric low protein diet during pregnancy and/or lactation on milk quantity and leptin concentration at postnatal day 7, 14, and 21. Control mothers ate 20% casein (C) and restricted mothers (R) 10% casein to provide four groups: CC, RR, CR, and RC (first letter pregnancy and second lactation diet) to enable evaluation of effects influenced by maternal diet during pregnancy and lactation. Milk leptin was not a determinant of pup serum leptin. Pup serum leptin did not inhibit milk appetite at any postnatal age. Pup serum leptin did not correlate with pup adipose tissue. Finally, the normal postnatal leptin rise in pup serum was delayed by prenatal undernutrition. These data suggest that fetal nutrition modifies timing of neonatal leptin surge and may contribute to the development of altered appetite and metabolic disorders in later life.

Idioma originalEnglish (US)
Páginas (desde-hasta)358-363
Número de páginas6
PublicaciónPediatric Research
Volumen63
N.º4
DOI
EstadoPublished - abr. 2008
Publicado de forma externa

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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