Effect of proteasome inhibitor 1 on wound healing: A potential scar prevention therapy

John A. Walker, Gianni Rossini, Michelle W. Thompson, Joseph C. Wenke, David Baer, Matthew Q. Pompeo, Bobby Dezfuli, Chin Shang Li, J. Nilas Young, Michael S. Wong, John F. Tarlton, Hugh S. Munro

Producción científica: Articlerevisión exhaustiva

1 Cita (Scopus)


In vitro and in vivo assessments suggest that proteasome inhibitors may be useful for modulating wound healing. Methods. Proteasome Inhibitor I was used to assess the potential utility of proteasome inhibitors in improving wound healing in a standard rat model. Bilateral, 6 cm incisions were made 1 cm lateral to the spine of adult male Sprague Dawley rats. Animals were randomly assigned to 1 of 3 groups: no treatment (n ≤ 15), low concentration (1% w/v, n ≤ 15), or high concentration (5% w/v, n ≤ 15). Treatments were applied to the left side incision at 0 hours, 24 hours, and 48 hours. Right-side incisionsreceived a vehicle, dimethyl sulfoxide, alone and independent of the assigned group, serving as both external and internal controls. Rats were sacrificed at days 7, 14, and 28 (n ≤ 5 per group) and wounds subjected to mechanical testing and histology. Results. No significant intergroup difference existed at 7 and 14 days. On day 28, a dosedependent increase in tensile strength with increasing Proteasome Inhibitor I was observed. Conclusion. Results suggest dimethyl sulfoxide was not the ideal vehicle and additional improvement may be realized by optimizing the delivery method.

Idioma originalEnglish (US)
Páginas (desde-hasta)28-33
Número de páginas6
EstadoPublished - feb 2013

ASJC Scopus subject areas

  • General Medicine


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