Effect of maternal nicotine on the development of sites for [3H]nicotine binding in the fetal brain

N. Hagino, J. W. Lee

Resultado de la investigación: Articlerevisión exhaustiva

91 Citas (Scopus)


The sites for [3H]nicotine binding in fetal brains were examined after administration of nicotine into pregnant rats. Administration of unlabelled nicotine into the pregnant rats increased Bmax values for the sites for [3H]nicotine binding without affecting Kd values in the fetal brains. Treatment with this regimen, however, did not show any significant change in the sites for [3H]quinuclidinyl benzylate (QNB) binding. In addition, treatment with this regimen increased Bmax values of the sites for [3H]nicotine binding in the brains of pregnant rats. α-Bungarotoxin had no effect on the sites for [3H]nicotine binding. It is inferred, therefore, that a similar response is elicited by nicotine binding sites to administered nicotine in both the fetal and maternal brains. Furthermore, a possible effect of nicotine in pregnant rats may be the facilitation of the development of nicotine acetylcholine receptors in the fetal brain.

Idioma originalEnglish (US)
Páginas (desde-hasta)567-571
Número de páginas5
PublicaciónInternational Journal of Developmental Neuroscience
EstadoPublished - 1985
Publicado de forma externa

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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