Resumen
The sites for [3H]nicotine binding in fetal brains were examined after administration of nicotine into pregnant rats. Administration of unlabelled nicotine into the pregnant rats increased Bmax values for the sites for [3H]nicotine binding without affecting Kd values in the fetal brains. Treatment with this regimen, however, did not show any significant change in the sites for [3H]quinuclidinyl benzylate (QNB) binding. In addition, treatment with this regimen increased Bmax values of the sites for [3H]nicotine binding in the brains of pregnant rats. α-Bungarotoxin had no effect on the sites for [3H]nicotine binding. It is inferred, therefore, that a similar response is elicited by nicotine binding sites to administered nicotine in both the fetal and maternal brains. Furthermore, a possible effect of nicotine in pregnant rats may be the facilitation of the development of nicotine acetylcholine receptors in the fetal brain.
Idioma original | English (US) |
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Páginas (desde-hasta) | 567-571 |
Número de páginas | 5 |
Publicación | International Journal of Developmental Neuroscience |
Volumen | 3 |
N.º | 5 |
DOI | |
Estado | Published - 1985 |
Publicado de forma externa | Sí |
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology